Rejuran vs Profhilo vs Skin Boosters Singapore: Which Is Right for You? (2026)
Published June 18, 2026 | Expert reviewed by team | Last updated: June 2026
“Skin booster” has become a catch-all term in Singapore for a wave of injectable treatments that improve skin quality rather than add volume. The three names you’ll hear most — Rejuran, Profhilo and skin boosters — are often used interchangeably, but they’re genuinely different treatments with different jobs.
This guide breaks down what each one actually is, what it’s best for, how many sessions you’ll need, how long results last, the cost in Singapore, and how to choose between them (or combine them).
Quick Comparison
| Treatment | What it is | Best for | Results last | Price (SGD) |
|---|---|---|---|---|
| Rejuran | Polynucleotide (salmon DNA) | Acne scars, repair, sensitive skin | Up to 12 months | ~$400–1,000 / session |
| Profhilo | Ultra-high HA bio-remodeller | Hydration, elasticity, light lift | Up to ~6 months | ~$700–1,200 / session |
| Skin boosters | Micro-droplet HA (e.g. Restylane) | Hydration, glow, fine lines | ~6–9 months | ~$200–800 / ml |
Indicative ranges — most clinics sell 2–4 session packages. Confirm at consultation.
What Is Rejuran?
Rejuran is the brand name for a polynucleotide (PN / PDRN) treatment — regenerative fragments purified from salmon DNA. Rather than adding volume, it works at a cellular level to stimulate collagen, calm inflammation and help the skin repair itself. That makes it the standout choice for acne scars, damaged skin barriers, sensitivity and texture. It comes in variants — Healer (general repair), S (acne scars), HB (added hydration) and I (delicate under-eye area). Most people need 3–4 sessions spaced 3–4 weeks apart, with results developing over 2–4 weeks and lasting up to 12 months.
What Is Profhilo?
Profhilo is an injectable bio-remodeller made of ultra-high-concentration hyaluronic acid (both high and low molecular weight). It spreads through the deeper layers of skin to deliver intense hydration while stimulating collagen and elastin — improving elasticity, firmness and overall glow, with a subtle lifting effect. It’s typically given as just 2 sessions one month apart, with results lasting around 6 months. For more detail and where to get it, see our guides to Profhilo clinics in Singapore and Profhilo benefits for women in their 20s.
What Are Skin Boosters?
“Skin boosters” usually refers to micro-droplet hyaluronic acid injectables such as Restylane Skinboosters or Teosyal Redensity. Tiny amounts of HA are injected across an area to deeply hydrate, plump fine lines and create that sought-after “glass skin” glow. They’re excellent for dehydration, dullness and early fine lines, generally given as a course of about 3 sessions spaced 4 weeks apart, with results lasting 6–9 months.
Head-to-Head — Which Should You Choose?
Match the treatment to your main concern:
- Acne scars & texture: Rejuran — its regenerative action is the standout here.
- Deep hydration & glow: Skin boosters (or Rejuran HB).
- Elasticity, laxity & subtle lift: Profhilo.
- Sensitive or compromised skin: Rejuran, for its healing properties.
- Delicate under-eye area: Rejuran I or a targeted skin booster.
- Best result with fewest sessions: Profhilo (just 2 sessions).
Cost Comparison in Singapore
Per session, Rejuran typically runs ~$400–1,000, Profhilo ~$700–1,200, and skin boosters ~$200–800 per ml. Because each needs a course, most clinics sell 3-session packages from roughly $1,200 to $3,900 depending on the product and technique. As with all injectables, prices can’t be publicly advertised in Singapore, so exact fees are confirmed at consultation — and the cheapest option is rarely the right benchmark.
Can You Combine Them?
Yes — and many patients in Singapore do. A common approach pairs Rejuran (for repair and texture) with an HA skin booster or Profhilo (for hydration and bio-remodelling) to address both structure and skin quality. A good doctor will sequence them sensibly across your treatment plan rather than doing everything at once.
Frequently Asked Questions
Which is best for acne scars?
Rejuran — particularly the Rejuran S variant — is the go-to for acne scarring because polynucleotides actively stimulate repair. It’s often combined with laser for deeper scars.
Rejuran vs Profhilo — which lasts longer?
Rejuran results can last up to 12 months, longer than Profhilo’s ~6 months — but they target different things (repair vs hydration and elasticity), so longevity alone shouldn’t decide it.
Is there downtime?
Minimal. Expect slight redness and small injection bumps or mild swelling for 24–48 hours. Avoid intense exercise for a day.
How soon will I see results?
Hydration improvements can show within a week; collagen-driven changes build over 2–8 weeks, with peak results around 2–3 months after a completed course.
What’s the difference between a skin booster and a filler?
Skin boosters improve skin quality and hydration across an area; fillers add structural volume to a specific spot. See our guide to dermal fillers in Singapore for the difference.
Final Thoughts
There’s no single winner between Rejuran, Profhilo and skin boosters — only the best fit for your skin. Choose Rejuran for repair and acne scars, Profhilo for elasticity and a glow with minimal sessions, and skin boosters for deep hydration. Better still, let an experienced doctor assess your skin and design the right plan, because for these treatments the hands matter as much as the product.
Comparing all your anti-ageing options? Read our complete guide to Profhilo clinics in Singapore
This article is for general information only and is not medical advice. Always consult a licensed doctor before any aesthetic treatment.
